A New Frontier at the Interface of Life and Light
The fastest processes in biology originate from the motion of electrons. The fastest tool available to control them is light. TRILOGY brings these two worlds together by developing the science of ultrafast chirality, where light fields controlled on attosecond time scale interrogate and manipulate the electronic origins of molecular handedness. This frontier connects fundamental quantum science with future biomedical and photonic technologies.
Ultrafast Chirality
Understanding molecular handedness through electron motion on the attosecond timescale. By probing chirality at its electronic origin, we unlock fundamentally new observables and unprecedented sensitivity.
Photoelectron Circular Dichroism (PECD)
Photoelectron Circular Dichroism is one of the most sensitive probes of molecular chirality. When chiral molecules are ionized by circularly polarized light, they emit electrons preferentially in the forward or backward direction, creating a strong enantio-sensitive asymmetry. Unlike conventional chiro-optical techniques, PECD relies on electric-dipole interactions and can enhance chiral sensitivity by orders of magnitude.
Time-Resolved PECD
Time-resolved PECD extends this concept into the ultrafast domain, tracking chiral electron dynamics in real time. It reveals how electronic wave packets evolve, how molecular structure changes after excitation, and how chirality emerges and evolves on femtosecond and attosecond timescales.
Synthetic Chiral Light
Tailored laser fields whose polarization traces a three-dimensional chiral trajectory in time create locally chiral light that couples directly to electronic motion. This allows chirality to be probed through efficient electric-dipole interactions, boosting chiral signals by orders of magnitude compared with conventional optical techniques and enabling new approaches to chiral detection, control, and spectroscopy.
Geometry & Topology in Ultrafast Chiral Dynamics
We explore the geometric structure of ultrafast electron dynamics in chiral matter. Using concepts such as geometric phases and Berry curvature, we reveal how molecular handedness generates topological observables. This framework uncovers the chirality of temporal structures formed by electronic currents and light fields, enabling robust topology-based approaches to chiral spectroscopy and control.
Chiral Biomolecules
From amino acids to nucleic acids and pharmaceuticals, chirality shapes biological function. We develop new methods to reveal molecular structure, folding, and dynamics with ultrahigh sensitivity. Our approaches enable structural characterization of biomolecular ions and their conformational transformations, bridging chiral spectroscopy and next-generation molecular analytics.
Charge and Spin Dynamics
Chiral matter influences the motion of electrons and spins. Understanding these processes is key to emerging concepts in molecular electronics, spintronics, and quantum technologies. TRILOGY investigates how molecular chirality controls ultrafast charge and spin dynamics, revealing the fundamental mechanisms behind chiral-induced spin selectivity and enabling new approaches to spin control with tailored light fields.
Photonic Technologies
We translate discoveries in ultrafast chirality into compact sensing technologies, combining lasers, photonics, microfluidics, and advanced analytics. These platforms bring attosecond science out of the laboratory, enabling scalable, high-throughput chiral sensing through the integration of advanced imaging and miniaturized photonic devices.
Biomedical and Environmental Applications
Applications range from disease biomarkers and pharmaceutical analysis to environmental monitoring, enabling next-generation tools for health, industry, and sustainability.
Doctoral Candidate Projects
TRILOGY recruits 16 doctoral candidates across the network, each pursuing an individual research project with co-supervision and mandatory secondment periods at partner institutions.
Generation of locally chiral, globally topological light inside optical Quipu fibers
WP3SKILLS AND CAREER PROSPECTS
Optics, intense light propagation in fibers/wave-guides, structured light, opportunity to participate in experiments and respective experience in fiber optics, and fiber lasers. Excellent prospects both in academia and high-tech industry.
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Ultrafast chiral response and charge directed reactivity
WP1 · WP2SKILLS AND CAREER PROSPECTS
Training in state-of-the-art table top attosecond sources, fiber laser tech. Applications in advanced photonics, light harvesting, medical and pharma.
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Chiral photoionization using structured light
WP1 · WP2SKILLS AND CAREER PROSPECTS
Expertise in core ultrafast technologies (primary and secondary ultrafast sources, attosecond spectroscopy, vacuum technology, particle detection, photoelectron and photoion spectroscopy) as well as in multidimensional data analysis.
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Before 15/06/26↗
Theoretical investigation of spin dynamics in strong-field ionization of chiral molecules
WP2SKILLS AND CAREER PROSPECTS
High performance computing, numerical modeling of non-stationary quantum systems, microscopic & macroscopic. Such skills are in high demand across many physics disciplines and industry, e.g. hydrodynamic flows (aeronautics), straindeformations (medical industry, engineering), etc, and also required skills in IT companies outsourcing ongoing industrial developments.
Generation of high rep-rate tunable ultrashort light pulses
WP1 · WP2SKILLS AND CAREER PROSPECTS
Cutting edge laser technology and applications. Industrial training combined with challenging research application opens wide career opportunities in ultrafast science, engineering, laser applications in biology and medicine.
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Enantiosensitive dynamics at conical intersections (CI)
WP2SKILLS AND CAREER PROSPECTS
High performance computing, use of GPUs, methods in electronic structure and quantum dynamics, expertise in modeling chirality, a field of the highest importance for academia, pharma, bio, materials, sensors. Fit for IT sector.
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Generation of chiral light in nano-devices for optical probes of chiral biomarkers
WP3SKILLS AND CAREER PROSPECTS
Skills in ultrafast laser sources, femtosecond laser micromachining, ultrafast spectroscopy, material science, data analysis, and vacuum technologies. Excellent prospects with such a skill set both in academia and high-tech industry.
All-optical chiral detection with temporally structured light
WP3SKILLS AND CAREER PROSPECTS
Expertise in ultrafast laser sources, vacuum technology, HHG spectroscopy, advanced data analysis, image processing, and ultrafast science in general are in very high demand in academia and high tech, e.g. laser, industry.
First principles description of ultrafast charge and spin dynamics in chiral molecules
WP1SKILLS AND CAREER PROSPECTS
In-depth understanding of electronic structure and ultrafast electron and spin dynamics, expertise in programming, scripting, advanced data processing and artifical intelligence in the natural sciences, intellectual property, project management.
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Design and Micromachining of Microfluidic Devices for Chiral Sensing Applications
WP3SKILLS AND CAREER PROSPECTS
Skills in femtosecond laser micromachining, materials science, computer-aided design, surface chemistry, fluid dynamics. Excellent prospects with such a skill set both in academia and high-tech industry.
Chiral photoelectron spectroscopy of molecular ions
WP3SKILLS AND CAREER PROSPECTS
Design and operation of complex ion-optical systems, expertise in ultrafast lasers, photoelectron spectroscopy, advanced data processing, analytical and numerical tools for ion and light optics, intellectual property, project management, high vacuum, high voltages. Extremely high demand for such researcher at an instrumentation vendor.
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Enantiosensitive imaging and manipulation with locally chiral evanescent waves
WP3SKILLS AND CAREER PROSPECTS
Quantum chemistry, electronic structure, and quantum dynamics in organic molecules, wave propagation in nanophotonic structures, general nanophotonics, nano-fiber design, attosecond molecular physics. High performance computing, use of GPUs, expertise in modeling chirality, a field of the highest importance for academia, pharma, bio, materials, sensors. Fit for IT sector.
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Chiral RABBITT
WP3SKILLS AND CAREER PROSPECTS
Analytical and numerical tools to model light propagation, high harmonic generation, attosecond interferometry, reaction microscope, state-of-the-art table-top attosecond sources. These skills are in very high demand in academia, expertise in table top (high harmonic) XUV sources is in very high demand in industry (e.g. ASML).
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Developing improved strategies for imaging photoelectron dichroism
WP1 · WP2SKILLS AND CAREER PROSPECTS
Extensive training in numerical modelling and analysis of big datasets – highly desirable/transferrable skills. Experience in ultrafast lasers, ultra-high vacuum technology, photoelectron imaging, broadly applicable in academia and industry.
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Time-Resolved approaches for transient vibronic chirality
WP2SKILLS AND CAREER PROSPECTS
Experience in ultrafast lasers, ultra-high vacuum technology, photoelectron imaging and information retrieval, heterodyne detection, coincident detection (electron/ion), non-linear optics, high harmonic generation, UV pulse compression, light polarimetry. High demand in academia and industry.
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Before 15/06/26↗
Enable chiral ion spectroscopy analysis on a high-resolution mass spectrometer
WP1SKILLS AND CAREER PROSPECTS
Analytical and measurement sciences, expertise in lasers, expertise in mass spectrometry, oligonucleotide and small molecule analysis, advanced data processing, impact on biomedical and pharmaceutical research, intellectual property, project management, high demand in (bio)pharma or instrument manufacturers.